Source: http://the-gadgeteer.com/2011/12/29/philips-fidelio-soundring-portable-speaker-with-airplay/
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Source: http://the-gadgeteer.com/2011/12/29/philips-fidelio-soundring-portable-speaker-with-airplay/
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BANGKOK (AP) ? Asian stocks markets fell Wednesday, with trading thinned by year-end holidays and mixed economic news out of the U.S. and Japan.
Benchmark oil remained above $101 per barrel while the dollar strengthened against the euro but fell against the yen.
Japan's Nikkei 225 index fell marginally to 8,430.32. Hong Kong's Hang Seng Index fell 0.7 percent to 18,503.67, while South Korea's Kospi lost 1.1 percent to 1,822.73. Australia's S&P ASX 200 lost 1.2 percent to 4,091.30. Benchmarks in Singapore, Taiwan and Indonesia were also lower.
Bucking the trend was the New Zealand NZX 50, which rose 0.7 percent to 3,236.90. Falling between the Christmas holiday and New Year's, trading throughout the region was generally light.
Japan's industrial output dropped a seasonally adjusted 2.6 percent last month ? the first decline in two months. But the negative news was mitigated by expectations of rebounding manufacturing and production this month and next, which helped to keep stock market losses minimal.
In mainland China, investors were "dumping shares" because Beijing has failed to take steps they expected to stimulate slowing economic growth, said Peter Lai, investment manager for DBS Vickers in Hong Kong.
"Some investors believed there would be a reduction in interest rates or the bank reserve ratio. But this hasn't happened. That is why people are dumping shares," Lai said.
Lai said some investors are moving money from China to the United States or Europe on hopes for better economic conditions and bigger returns.
The Shanghai Composite Index shed 0.7 percent to 2,151.97. The smaller Shenzhen Composite Index sank 1.8 percent 838.25.
Tokyo Electric Power dropped 12.3 percent, a day after Japanese Industry Minister Yukio Edano suggested that the embattled utility be put under temporary state control and warned the company against resorting to electricity bill hikes.
TEPCO operates the Fukushima Dai-ichi nuclear power plant, which was heavily damaged in the March earthquake and tsunami, and owes massive compensation payments to people and companies harmed by a nuclear disaster at the plant.
Hong Kong-listed property shares also slumped. China Vanke Co. fell 2 percent and China Overseas Land & Investment slid 3 percent.
China Mengniu Dairy, the country's biggest dairy company, plummeted 22.6 percent in Hong Kong after acknowledging that a cancer-causing toxin had been found in milk produced by the company. Mengniu apologized and said no tainted milk had made it to the market. The government blamed the problem on bad feed given to cows.
On Wall Street on Tuesday, the Dow Jones lost less than 0.1 percent to close at 12,291.35. The S&P 500 was up marginally to 1,265.43. The Nasdaq composite rose 0.3 percent to 2,625.20.
U.S. consumer confidence surged to an eight-month high, but home prices fell in 19 of the 20 cities tracked by the Standard & Poor's/Case-Shiller index. That report dampened investors' enthusiasm about a jump in consumer confidence to the highest level since April.
Benchmark crude oil rose 2 cents to $101.36 per barrel in electronic trading on the New York Mercantile Exchange. The contract rose $1.66 to finish at $101.34 per barrel on the Nymex on Tuesday.
In currency trading, the euro fell to $1.3062 from $1.3069 late Tuesday in New York. The euro has been weak because of worries about Europe's government debt crisis. It is still trading just above an 11-month low of $1.2943 reached on Dec. 14.
The dollar fell to 77.76 yen from 77.85 yen.
___
AP Business Writer Joe McDonald contributed from Beijing.
Associated Pressgeoffrey mutai wes welker brandon jacobs brandon jacobs fred davis fred davis fracking
Oops: Droid 4 makes an early appearance in Best Buy promo originally appeared on Engadget on Thu, 29 Dec 2011 12:16:00 EDT. Please see our terms for use of feeds.
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Dave Kerpen
Source: http://twitter.com/DaveKerpen/statuses/151498417561026561
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A few weeks ago, I noted the remarkably keen sense of smell exhibited by Pinellas County, Florida,?sheriff's deputies, who claimed they could tell, standing outside the homes of people who had purchased hydroponic gardening equipment, which ones had marijuana plants inside, simply by following their noses. But the St. Peterburg Times reports that?the deputies' olfactory perceptions are not always accurate:
According to a Sheriff's Office report, detectives saw [Shane] Metler's car at Simply Hydroponics [a Largo store monitored by a surveillance camera] on Dec. 18, 2010. On the evening of July 7, two detectives and a deputy knocked on Metler's door.
He said the detectives told him they had gotten complaints from his neighbors about cars coming and going, and they had detected the smell of growing marijuana coming from his home, both charges he vehemently denies.
Metler, 35, allowed them to search the house he shares with his girlfriend. They did not find any marijuana or pot plants, but did find a soil-free hydroponic system being used to grow legal plants, according to their notes.
"I have to admit, it really shook us up," Metler said. "So, for the next four hours, we were pacing around the house and just bewildered, shocked. It really was disrupting."
Metler said he consented to the search because he knew he wasn't doing anything illegal.
But, he said, the visit put him in a "lose-lose situation, where I either look guilty or give up my rights as a citizen."
Another customer of Simply Hydroponics, Jeremy Harris, was visited by a dozen or so deputies who claimed to be acting on an anonymous tip. He consented to the search, which turned up nothing illegal. He told the Times:
They looked like full SWAT. They've got the vests and assault rifles. It just seemed like an awful excessive amount of force for somebody that is maybe just growing marijuana on the property. They showed up with enough force to deal with a drug cartel....
It doesn't seem right for them to be watching a business and then harassing the customers, basically just for shopping at that business.
The paper identified 34 such "knock and talk" searches by the sheriff's office between January 1, 2010, and September 15, 2011, 12 of which "found no marijuana and no marijuana plants."
Back in the early 1990s, when the Drug Enforcement Administration was carrying out searches like these under Operation Green Merchant, I asked a spokesman how often they came up empty. He said the DEA did not keep track of that figure and professed surprise at the idea that anyone would want to know.
Lest you think that attitude is limited to law enforcement officials, note that Jeremy Harris' mother, with whom he lives, did not share his negative reaction to the search of their home:
"I don't feel they violated my rights. They asked to search and I gave them permission," Nancy Harris said.
Harris said she was "happy" detectives searched her home because it showed dedication to fighting drug use and sale, an effort she supports.
Harris also said she felt the deputies acted professionally, taking special care not to disturb her three grandchildren.
"They didn't scare the children. They didn't disturb the children. They were very polite, and apologetic afterward," she said.
[Thanks to Richard Cowan for the tip.]
Source: http://reason.com/blog/2011/12/27/sir-your-perfectly-legal-plants-smell-li
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A plus of consolidation is that students will only have to make one monthly payment; a minus could mean that the borrower makes more payments and pays more in total interest, according to Chris Collins, the associate director of the San Diego State University, or SDSU, Office of Financial Aid and Scholarships. In this interview, Collins discusses the benefits -- and the pitfalls -- recent graduates might gain by taking out consolidation loans.
What advice would you give to recent graduates who are burdened with paying off student loans?
(It is hoped) the former student is starting from a good place by having managed his or her borrowing appropriately and only taking those loans needed for educationally related expenses. There is not an overriding interest rate benefit to be gained by a consolidation loan since servicers and the government use a weighted average on the loans being consolidated. It is more a matter of convenience, as the borrower will only have one monthly payment to make. Students who experience a financial hardship, such as not being able to find a job or being underemployed, can seek other remedies to postpone their loan payments, including deferment and forbearance. There are also alternate loan repayment plans including extended, graduated and income-based repayment that can reduce the amount of the monthly payment owed by the borrower.When considering college loan consolidation, is it better to consider federal loans or private loans?
Generally speaking, private loans cannot be consolidated with federal student loans, and not all private lenders offer consolidation. When a lender is willing to consolidate private loans, the primary benefit is that the borrower gets a single monthly payment. Students should check with individual lenders about their consolidation policies and always pay special attention to the fine print in any agreement they are considering.What are the pros and cons of college loan consolidation?
The pros would include that there is no cost to consolidate and the student will only have to make one monthly payment. The student can also benefit from the fact that the single monthly payment can be lower overall than the combined payments of unconsolidated loans. However, if the length of the repayment period is increased, it would mean that the borrower makes more payments and pays more in total interest. In addition, a borrower could lose benefits offered as a condition of the original loans.According to an article published by Consumer Reports last May, the average debt per graduate, class of 2011, is $22,900. If you are among the masses bogged down by college loans, it might help to know that you are not alone, but it will help more to know the pros and cons of debt consolidation so you can begin to make your way to financial freedom.
We would like to thank the associate director of the SDSU Office of Financial Aid and Scholarships, Chris Collins, for sharing his insights.
More From Bankrate.com
Source: http://c.moreover.com/click/here.pl?r5664432850
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LONDON (Reuters) ? Queen Elizabeth's 90-year-old husband Prince Philip left a British hospital on Tuesday after undergoing successful surgery to clear a blocked heart artery.
With the window of the jeep he was travelling in wound down, Philip waved at the media as he left Papworth hospital near Cambridge.
Philip, who was rushed into hospital by helicopter on December 23, has missed most of the royal family's Christmas festivities. The queen and Philip's grandchildren, including Prince William and Prince Harry, have visited him in hospital.
Philip was on his way to his family's rural Sandringham estate in eastern England, Buckingham Palace said.
(Reporting by Rosalba O'Brien; Editing by Alessandra Rizzo)
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Independent Senator Joseph Lieberman chairs the Senate Homeland Security and Governmental Affairs Committee. Elected to the Senate in 1988, he ran as an independent in 2006 after losing Connecticut's Democratic primary. He spoke at the Dec. 13 Monitor breakfast in Washington.
Why public approval of Congress is so low:
"Because I don't think Congress has ever been as bad as it is today. Here is a time of very serious, painful economic hardship ... and a debt that is threatening our future, national debt, and we really haven't done anything about it."
Whether members of Congress are using non-public information for personal financial gain:
"I don't have any evidence that there is insider trading by members of Congress.... A lot of people around the country ... think there is.... It is very important that Congress make clear with legislative action that members of Congress ... are covered by insider-trading laws."
President Obama's response to Iran's capture of an American spy drone:
"I wish that we had found a way to at least go in and destroy it.... It would have been very difficult to rescue it.... I say that with humility because I wasn't in the [White House] Situation Room...."
US policy toward Iran:
"I don't think we have done enough to support regime change. It needs to be done artfully because it is not one of those cases where we want to go in and start endorsing opposition" candidates.
Former Speaker Newt Gingrich saying the Palestinians are an "invented" people:
"To me, the important fact is, the Palestinians are a people today and any resolution of the conflict between Israel and the Palestinians has to be between two peoples, two nations."
Calls for the Transportation Security Administration to create passenger advocates at airports to deal with complaints about searches:
"It is worth thinking about, but I am not jumping to endorse it.... I am an admirer of TSA."
Source: http://us.rd.yahoo.com/dailynews/rss/terrorism/*http%3A//news.yahoo.com/s/csm/20111225/ts_csm/437874
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The University of Oregon is a public university located in Eugene, Oregon. The university was founded in 1876, graduating its first class two years later. The University of Oregon is one of 60 members of the Association of American Universities. The Carnegie Foundation classifies the University of Oregon as a "high research activity" university. Former Oregon Attorney General David B. Frohnmayer is the president of the university. The UO receives much of its funding from the UO Foundation, an independent not-for-profit organization.
Source: http://explorer.altopix.com/map/9at8vz/298/239/University_of_Oregon.htm
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The Sony VPL-HW30ES ($3,700 street), is one of several recently announced models that, as a group, are about to ratchet up once again the features you should expect in a home theater projector. About two years ago, the price for 1080p resolution fell dramatically. That was followed by 1080p models with 3D. However, the 3D worked only at 720p and needed a video converter to work with most sources. The VPL-HW30ES and other new generation models offer 1080p in 2D and 3D, and they work directly with Blu-ray players, FIOS, and the like. Most important, the Sony projector in particular offers high enough image quality and enough capability to more than justify the price.
The VPL-HW30ES is much cheaper than Sony's previous lowest-cost 1080p 3D projector, which was about $10,000. However, it's more expensive than some other current choices. In particular, it costs more than twice as much as the Optoma HD33 ($1,500 street, 4 stars) that I recently reviewed. And note that the VPL-HW30ES?s price doesn't even include the cost of the external 3D emitter ($80 street) or 3D glasses ($130 street each).
Sony also sells the projector as the Sony VPL-HW30AES with the emitter and two sets of glasses, but at $3,999 (street), it doesn't save much over buying the pieces separately. Either way the projector represents a fairly serious investment by most people's standards.
What makes the VPL-HW30ES potentially worth the extra cost compared with the Optoma HD33 is a combination of features. Most significant is that it's built around SXRD panels, Sony's version of LCOS. The technology avoids both the screen-door effect of LCD projectors and the rainbow artifacts that single-chip DLP projectors like the HD33 can show. (The screen door effect refers to a visible grid defining the pixels, which you can see if you sit close to the screen. The rainbow effect consists of light areas breaking up into little red-green-blue rainbows when you shift your gaze or an object moves on screen.)
The VPL-HW30ES also offers conveniences like vertical and horizontal lens shift that the HD33 leaves out, a 1.6x zoom lens, 2D to 3D conversion, excellent image quality for both 2D and 3D, and enough flexibility in brightness to make it appropriate both for a traditional home theater with theater dark lighting and for rooms with some ambient light.
Setup
The VPL-HW30ES is a relatively large beast, at 7.1 by 16.1 by 18.4 inches (HWD), and it weighs 22.1 pounds. However, that's not unusual for a home theater projector. Two strictly 2D Editors' Choices, for example, the Epson PowerLite Home Cinema 8700 UB ($2,199 direct, 4 stars) and the Epson PowerLite Home Cinema 8350 ($1,299 direct, 4 stars), are both only a little smaller.
Basic setup, meaning connecting cables and getting the projector working, is easy. The 1.6x manual zoom gives you lots of flexibility in how far you can put it from the screen for a given size image, and the horizontal and vertical lens shift gives you flexibility in positioning it left, right, up, or down relative to the screen. The vertical lens shift can move the image by roughly 65% of a screen height up or down from the midpoint. The horizontal shift can move it by about 25% left or right.
Connectors on the side of the projector include two HDMI ports, one VGA port, a set of three RCA phono plugs for component video, an RS-232 serial port for controlling the projector from a computer or control box, and an RJ-45 for the external 3D IR emitter.
Setting up the emitter can be a challenge, because you need a clear line of sight from the emitter to the proprietary 3D glasses. Pointing it so the signal will bounce off the screen can work, but it also leads to the glasses losing sync occasionally, which can be disconcerting. An additional complication is that the manual specifies that you have to use a category 7 network cable, which isn't included, to connect the emitter, and it can't be more than 15 meters long. I used a category 6 cable successfully, but it was only 3 feet long.
More Setup
Once you have the basic setup finished, you're ready for the hard part. First, you'll want to make sure that the brightness is appropriate for the screen size and lighting conditions. With the 78-inch wide (92-inch diagonal) image we normally use for testing, for example, the default settings for the projector were about right for a moderate level of ambient light, but way too bright for comfortable viewing in theater dark lighting.
You can lower the brightness by setting the lamp to low, which also increases rated lamp life from 2,000 to 3,000 hours. You can also set the iris control to manual and then adjust it to lower the brightness further. Between the two settings, I had no trouble getting the brightness low enough to be suitable for theater dark conditions.
You'll also need to experiment with some of the more advanced options to decide which settings you prefer. In particular, you'll want to play with the MotionFlow setting, which adds interpolated frames to reduce judder, the slightly jerky motion that's inherent in the standard 24 frame per second film speed.
As with Optoma's equivalent PureMotion feature, MotionFlow works to smooth the image, but the highest setting also introduces artifacts that I found distracting. The low setting was the best compromise for my tastes, but you may feel differently.
You may even prefer to turn the feature off entirely. Adding interpolated frames to remove judder also gives movies the look and feel of live video, which you may or may not consider desirable. You may also decide that you like the feature for watching, say, sports, but not for watching movies. The only way to find out is to experiment with the settings.
Finally, for setup, you should adjust the color to give you the best possible image. In theory, you can say the same for any home theater projector. If you're going to pay this much for one, however, you'd be foolish not to set it up just so. Getting the color right requires a fair level of knowledge, and some equipment that most people don't own, which means that you may want to pay someone to do it for you.
2D and 3D Image Quality
For judging 2D image quality in my tests, I used both DVDs upscaled to 1080p and Blu-ray discs. In both cases, the image lived up to Sony's reputation for great high-quality images. The VPL-HW30ES did a good job with all of our toughest test clips, maintaining shadow detail (detail based on shading in dark areas), doing a good job with skin tones, and generally avoiding problems that the clips are meant to bring out. For less demanding?and more typical?scenes, the image was excellent. I saw subtle levels of noise in large solid areas, like a blank wall, but much less than I saw with, for example, the HD33.
The 3D image quality earns much the same praise overall. I saw a touch of crosstalk (the ghost image that shows when the frame meant for one eye shows through to the other eye as well). However, I didn't see it often enough to find it bothersome. And note that you can reduce crosstalk by adjusting the 3D Glasses Brightness and 3D depth effect settings?still more options you'll need to experiment with to find the right settings for you. The projector also offers 2D to 3D conversion that works as promised.
By any measure the Sony VPL-HW30ES qualifies as an impressive projector. Keep in mind that as of this writing there a number of other 1080p 3D projectors that have been announced, including models from Epson and Panasonic that I'm waiting to get my hands on to review. But regardless of what else is waiting in the wings or is actually available by the time you read this, if you want excellent quality 2D and 3D without any risk of seeing a rainbow effect, the Sony VPL-HW30ES stands ready to deliver the image quality you're looking for.
More Projector Reviews:
??? Sony VPL-HW30ES
??? Epson VS315W Multimedia Projector
??? InFocus IN114
??? Epson PowerLite S9 Multimedia Projector
??? Dell 1410X
?? more
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"It takes a pair to beat the odds"Inspired by a true story, a comedy centered on a 27-year-old guy who learns of his cancer diagnosis, and his subsequent struggle to beat the disease. REVIEWThe film focuses on Adam, a Seattle-based NPR staffer whose comfortable life is turned upside down when he learns he has malignant tumors along his spine. With little empathy, the oncologist tells him he has a 50/50 chance of survival. Buoyed by his boisterous best friend Kyle, Adam tries to remain optimistic despite his overbearing mother Diane, who wants to move in with him right away despite acting as a caretaker for his father, an Alzheimer's victim. Remaining disturbingly distant is Adam's artist girlfriend Rachael who promises to stand by him and nurse him back to health. However, as he goes through his chemotherapy, her commitment to him unravels. The movie addresses the bitter irony of how those one would expect support Adam without condition are the ones who are the most likely to fail. At the same time, he grows closer to two fellow cancer patients, as well as Katherine, the awkward young therapist played by Anna Kendrick.The acting is effective without excess. As a last-minute replacement for James McAvoy, Joe Gordon-Levitt gives a nice, self-effacing performance as Adam that feels right for the passivity needed for the role. Playing a version of his real self since he is Reiser's best buddy and the one who encouraged him to write the script, Seth Rogen provides manic, shaggy-dog energy to Kyle as a direct counterpoint to Adam and then surprises by deepening his character as the story progresses. Bryce Dallas Howard plays Rachael as a more subtle version of the malevolent character she played in The Help, but she may be in danger of stereotyping herself in like-minded roles. Kendrick also plays a variation of a previous role as the ambitious careerist in Up in the Air, but she does a better job of transcending her character's youthful exuberance this time. Easily stealing her few scenes, Anjelica Huston brings back her much-missed ferocity to Diane. Unlike most, this is a most worthwhile "cancer" movie.
September 28, 2011Source: http://www.rottentomatoes.com/m/5050_2011/
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Apple doesn't officially offer the 32GB iPhone 4 anymore. After the introduction of the iPhone 4S, the iPhone 4 is being officially sold now as an 8GB model only, but stock of the 32GB models must remain. The 32GB iPhone 4 costs $199 plus 2 year contract. If you buy two from Best Buy today (in store only), you get the 2nd one free. Both need to sign up for two year contracts, but it's still a nice savings -- if you're in the market for two new iPhone 4 devices.
Source: http://feeds.macrumors.com/~r/MacRumors-iPhone/~3/Crmz2dVkj-o/
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A strange metal ball dropped out of the sky and slammed into the remote grassland of northern Namibia recently, according to press reports.
The 14-inch-wide (35-centimeter) metallic sphere hit the ground about 480 miles (750 kilometers) north of Windhoek, the African country's capital. It left a crater 13 inches (33 cm) deep and 12.5 feet (3.8 meters) across, the Agence-France Presse (AFP) reported Thursday (Dec. 22).
The metal "space ball" weighs 13 pounds (6 kilograms). It has a rough surface and appears to consist of two halves that were welded together, according to AFP.
The mystery sphere was discovered in mid-November, but local authorities held off on announcing the find until they could perform a few tests. They determined it poses no danger to the public.
"It is not an explosive device, but rather hollow, but we had to investigate all this first," police deputy inspector general Vilho Hifindaka told AFP.
However, Hifandaka and his colleagues still don't know what the object is or where exactly it came from. They've contacted NASA and the European Space Agency for help, AFP reported.
Locals apparently heard several small explosions a few days before the ball was found. Similar spheres have also been found in Australia and Central America over the last two decades, local authorities said.
Quite a bit of space junk has rained from the sky this year. In September, for example, NASA's defunct Upper Atmosphere Research Satellite (UARS) ? a 6.5-ton craft that monitored climate from 1991 until 2005 ? plunged into the atmosphere over the Pacific Ocean.
Just a month later, Germany's 2.7-ton Roentgen Satellite (ROSAT) fell to Earth over the Indian Ocean. Nobody on the ground was injured by either satellite crash.
An even bigger spacecraft will plummet to Earth soon. Russia's failed Phobos-Grunt Mars probe got stuck in Earth orbit shortly after its Nov. 8 launch, and it's been circling lower and lower ever since. Most experts predict the 14.5-ton spacecraft will come crashing down by mid-January.
Follow SPACE.com for the latest in space science and exploration news on Twitter @Spacedotcom and on Facebook.
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Over 18s, bring along photo ID
ABSTRACT AT PACHA
THE LAST CHRISTMAS PARTY OF 2011
December is traditionally the busiest month of the year in clubland and the Christmas party is always one of the biggest. We are delighted to announce that Pacha London will be holding its last Christmas party on Friday 23rd December.
Dusting away those holiday blues, and helping put back together those happy holiday moments will be Abstract, one of the rising parties of 2011
Expect the wild party atmosphere you can only experience with Pacha London - a slightly older more sophisticated crowd who love House, who love Pacha and love getting together in big groups of friends and making Pacha their playground for the night. You can expect the finest DJs, a show to take your breath away and the best entertainment around.
Main Room Ft. Fall from Grace
Femi B
Rodney Hicks b2b with Jack Lewis
Scott Costa
Sesan
Global Room Ft. Nightlife London
DJ Bobbie Anderson / Paul Pure / DJ Mr Mo / DJ Ted Amber / Vitas Merkel
DJ Filip Neves / FILIP NEVES / Andrew Ives / DJ Marcello / DJ RM Bergman / Duncan MacLoud
?15 on the door
Source: http://alist.ticketabc.com/events/abstract-last-christ/
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Contact: Mary Guiden
mary.guiden@seattlechildrens.org
206-987-7334
Seattle Children's
SEATTLE -- Physicians use inhalation anesthetics in a way that is incredibly safe for patients, but very little is known about the intricacies of how these drugs actually work in children and adults. Now, researchers have uncovered what cells respond to anesthesia in an organism known as the C. elegans, according to a new study from the Seattle Children's Research Institute. C. elegans is a transparent roundworm used often in research. The study, "Optical reversal of halothane-induced immobility in C. elegans," is published in the December 20, 2011 issue of Current Biology.
"Our findings tell us what cells and channels are important in making the anesthetic work," said lead author Phil Morgan, MD, researcher at Seattle Children's Research Institute and University of Washington professor of anesthesiology and pain medicine. "The scientific community has attempted to uncover the secrets of how anesthetics work since the 1860s, and we now have at least part of the answer." Margaret Sedensky, MD, Seattle Children's Research Institute and a UW professor of anesthesiology and pain medicine, and Vinod Singaram, graduate student, Case Western Reserve University, are co-lead authors of the study.
The team studied the roundworm after inserting a pigment or protein typically found in the retina of a human eye called a retinal-dependent rhodopsin channel into its cells. The proteins in cell membranes act as channels to help movement. Researchers then used a blue light, activating channels in the roundworm that allowed the immediate reversal of anesthetics, and resulting in the roundworm waking up and seemingly swimming off the slide. A video of a roundworm reacting to the blue light, waking up from anesthesia can be found here: http://www.youtube.com/watch?v=FhtFvKlnwxU
The team's findings won't immediately translate into a discovery that would be available for humans, cautioned Dr. Morgan, who has been working in this field for some 25 years. "But it tells us what function we have to treat to try to do so," he said.
"We believe that there is a class of potassium channels in humans that are crucial in this process of how anesthetics work and that they are perhaps the ones that are sensitive to potential anesthesia reversal. There are drugs for blocking these channels and with these same drugs, maybe we can eventually reverse anesthesia." Potassium channels are found in all living organisms and in most cell types, and they control a wide variety of cell functions.
Anesthesia medications are used in both children and adults, but many are used more often in kids. Dr. Morgan and his colleagues plan to replicate the study in other animal models, starting with a mouse.
###
Other co-authors for the study include: Benjamin Somerlot, graduate student, Case Western Reserve University; Dr. Scott Falk, University of Pennsylvania Perelman School of Medicine and Dr. Marni Falk, The Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine.
The study "Optical reversal of halothane-induced immobility in C. elegans," in Current Biology can be found here: http://www.cell.com/current-biology/abstract/S0960-9822(11)01203-6
About Seattle Children's Research Institute
At the forefront of pediatric medical research, Seattle Children's Research Institute is setting new standards in pediatric care and finding new cures for childhood diseases. Internationally recognized scientists and physicians at the Research Institute are advancing new discoveries in cancer, genetics, immunology, pathology, infectious disease, injury prevention, and bioethics. With Seattle Children's Hospital and Seattle Children's Hospital Foundation, the Research Institute brings together the best minds in pediatric research to provide patients with the best care possible. Children's serves as the primary teaching, clinical, and research site for the Department of Pediatrics at the University of Washington School of Medicine, which consistently ranks as one of the best pediatric departments in the country. For more information, visit http://www.seattlechildrens.org/research
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Contact: Mary Guiden
mary.guiden@seattlechildrens.org
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Seattle Children's
SEATTLE -- Physicians use inhalation anesthetics in a way that is incredibly safe for patients, but very little is known about the intricacies of how these drugs actually work in children and adults. Now, researchers have uncovered what cells respond to anesthesia in an organism known as the C. elegans, according to a new study from the Seattle Children's Research Institute. C. elegans is a transparent roundworm used often in research. The study, "Optical reversal of halothane-induced immobility in C. elegans," is published in the December 20, 2011 issue of Current Biology.
"Our findings tell us what cells and channels are important in making the anesthetic work," said lead author Phil Morgan, MD, researcher at Seattle Children's Research Institute and University of Washington professor of anesthesiology and pain medicine. "The scientific community has attempted to uncover the secrets of how anesthetics work since the 1860s, and we now have at least part of the answer." Margaret Sedensky, MD, Seattle Children's Research Institute and a UW professor of anesthesiology and pain medicine, and Vinod Singaram, graduate student, Case Western Reserve University, are co-lead authors of the study.
The team studied the roundworm after inserting a pigment or protein typically found in the retina of a human eye called a retinal-dependent rhodopsin channel into its cells. The proteins in cell membranes act as channels to help movement. Researchers then used a blue light, activating channels in the roundworm that allowed the immediate reversal of anesthetics, and resulting in the roundworm waking up and seemingly swimming off the slide. A video of a roundworm reacting to the blue light, waking up from anesthesia can be found here: http://www.youtube.com/watch?v=FhtFvKlnwxU
The team's findings won't immediately translate into a discovery that would be available for humans, cautioned Dr. Morgan, who has been working in this field for some 25 years. "But it tells us what function we have to treat to try to do so," he said.
"We believe that there is a class of potassium channels in humans that are crucial in this process of how anesthetics work and that they are perhaps the ones that are sensitive to potential anesthesia reversal. There are drugs for blocking these channels and with these same drugs, maybe we can eventually reverse anesthesia." Potassium channels are found in all living organisms and in most cell types, and they control a wide variety of cell functions.
Anesthesia medications are used in both children and adults, but many are used more often in kids. Dr. Morgan and his colleagues plan to replicate the study in other animal models, starting with a mouse.
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Other co-authors for the study include: Benjamin Somerlot, graduate student, Case Western Reserve University; Dr. Scott Falk, University of Pennsylvania Perelman School of Medicine and Dr. Marni Falk, The Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine.
The study "Optical reversal of halothane-induced immobility in C. elegans," in Current Biology can be found here: http://www.cell.com/current-biology/abstract/S0960-9822(11)01203-6
About Seattle Children's Research Institute
At the forefront of pediatric medical research, Seattle Children's Research Institute is setting new standards in pediatric care and finding new cures for childhood diseases. Internationally recognized scientists and physicians at the Research Institute are advancing new discoveries in cancer, genetics, immunology, pathology, infectious disease, injury prevention, and bioethics. With Seattle Children's Hospital and Seattle Children's Hospital Foundation, the Research Institute brings together the best minds in pediatric research to provide patients with the best care possible. Children's serves as the primary teaching, clinical, and research site for the Department of Pediatrics at the University of Washington School of Medicine, which consistently ranks as one of the best pediatric departments in the country. For more information, visit http://www.seattlechildrens.org/research
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Source: http://www.eurekalert.org/pub_releases/2011-12/sc-suc122111.php
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TOKYO (AP) ? Japan's government on Tuesday selected the Lockheed Martin F-35 stealth fighter to bolster its aging air force, announcing it will buy a total of 42 aircraft under a multiyear deal.
Japan has budgeted the cost of four fighters next fiscal year, which starts in April, said Noriyuki Shikata, deputy Cabinet secretary for public relations.
Lockheed gave the average price per plane as $65 million. Details including exact timing of the deliveries, final price tag and quantities per year have yet to be finalized.
Japan wrestled for years over whether to buy the F-35, Boeing F-18 or the Eurofighter Typhoon, made by a consortium of European companies. The U.S. planes were seen as the favorites because of close U.S.-Japan military ties.
The F-35, also called the Joint Strike Fighter, is the Pentagon's biggest weapons procurement program ? costing $238 billion ? and has support from allies including Britain, Australia, Canada, Israel and several European nations. It is to be used by the U.S. Air Force, Marines and Navy.
Japan ? with 362 fighter jets, mostly F-15s, F-4s and F-2s ? is already one of the top air powers in the region. But planners have long been concerned by the increasing age and expense of maintaining the fleet, along with Japan's ability to match the improving air capabilities of its neighbors.
The new fighters would replace the F-4s.
To further sweeten the deal, Lockheed promised Japan a share of the assembly and production of the aircraft, which is important to local producers.
Japanese officials said they took into account cost, performance and the inclusion of Japanese companies in the manufacturing process.
"Lockheed Martin is honored by the selection," said Dave Scott, the company's director of F-35 international business development based in Fort Worth, Texas. "We're excited about working with Japanese industry to manufacture and deliver the F-35 for the Japan Air Self-Defense Force."
Washington is Tokyo's main ally. Roughly 50,000 U.S. troops are stationed in Japan under a security pact. Japan's air force must work closely with its American counterpart, and using the same or similar equipment makes that easier.
Japan's main concerns are China and Russia ? with which it has long-standing territorial disputes ? along with the threat of North Korean ballistic missiles.
China, whose military has been growing more capable and assertive, recently rolled out its next-generation stealth fighter, the much-touted Chengdu J-20. Though it may be years away from actual operations, it is seen as a rival to the best U.S. fighters and far superior to what Japan now has.
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Associated Press writer Eric Talmadge contributed to this report.
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U.S. Secretary of Defense Leon Panetta, center right, with U.S. Ambassador to Libya Gene Crets, center left, and Gen. Carter Ham, Commander U.S. Africa Command, third from left, places a wreath at the grave site of 13 U.S. Navy sailors during a ceremony at the Protestant Cemetery in Tripoli, Libya, Saturday, Dec., 17, 2011. Panetta visited the grave site of the sailors, who where killed on the USS Intrepid in 1804. (AP Photo/Pablo Martinez Monsivais, Pool)
U.S. Secretary of Defense Leon Panetta, center right, with U.S. Ambassador to Libya Gene Crets, center left, and Gen. Carter Ham, Commander U.S. Africa Command, third from left, places a wreath at the grave site of 13 U.S. Navy sailors during a ceremony at the Protestant Cemetery in Tripoli, Libya, Saturday, Dec., 17, 2011. Panetta visited the grave site of the sailors, who where killed on the USS Intrepid in 1804. (AP Photo/Pablo Martinez Monsivais, Pool)
U.S. Secretary of Defense Leon Panetta and Libyan Prime Minister Abd al-Rheem Al-Keeb greet one another during their joint news conference in Tripoli, Libya, Saturday, Dec., 17, 2011. (AP Photo/Pablo Martinez Monsivais, Pool)
U.S. Secretary of Defense Leon Panetta, second from left, leaves the grave site of 13 U.S. Navy sailors at the Protestant Cemetery in Tripoli, Libya, after participating in a wreath laying ceremony Saturday, Dec., 17, 2011. Panetta visited the grave site of the sailors, who where killed on the USS Intrepid in 1804. (AP Photo/Pablo Martinez Monsivais, Pool)
U.S. Secretary of Defense Leon Panetta, center, leaves his challenge coin on the grave stone during the wreath laying ceremony with U.S. Ambassador to Libya Gene Crets, obscured third from left, and Gen. Carter Ham, second from left, Commander U.S. Africa Command, at grave site of 13 U.S. Navy sailors at the Protestant Cemetery in Tripoli, Libya, Saturday, Dec., 17, 2011. Panetta visited the grave site of the sailors, who where killed on the USS Intrepid in 1804. (AP Photo/Pablo Martinez Monsivais, Pool)
U.S. Sec. of Defense Leon Panetta, left, is presented with a gift during his meeting with Libyan Minister of Defense Usama al-Jwayli, right, in Tripoli, Libya, Saturday, Dec. 17, 2011. (AP Photo/Pablo Martinez Monsivais, Pool)
TRIPOLI, Libya (AP) ? U.S. Defense Secretary Leon Panetta said "the torch of freedom" has passed to the Libyan people and he pledged during a historic visit Saturday to Tripoli that the United States will do all it can to help the country move toward democracy.
But he and his Libyan hosts acknowledged the threat of Islamic militants gaining ground in this period of political uncertainty following the ouster and death of longtime dictator Moammar Gadhafi.
Panetta and Libyan leaders identified challenges for the government now forming, including how to gain control of the militias that overthrew Gadhafi during an eight-month civil war.
"This will be a long and difficult transition, but I have confidence that you will succeed in realizing the dream of a representative government," Panetta said during a news conference with Prime Minister Abdurrahim el-Keib.
"The torch of freedom that has passed throughout the centuries and now passes from nation to nation in the Middle East and North Africa burns brightly here in Libya. May it light your way to a future of peace, prosperity and freedom," Panetta said.
While his visit was brief, Panetta made history as the first U.S. Pentagon chief to set foot on Libyan soil.
He evoked U.S. history, too, with a visit to the cemetery presumed to hold remains of U.S. sailors killed in Tripoli harbor in 1804. Their deaths were memorialized in the famous "shores of Tripoli" line in the Marine Corps hymn.
Both Panetta and al-Keeb expressed confidence that the fledgling government will be able to reach out to the militias and bring them together.
"We know how serious this issue is," said al-Keeb, "We realize it is not matter of saying 'OK, put down your arms, go back to work or do what you want to do.' We realize that there are lots of things that we need to be organized."
More broadly, Panetta said the revolts across the region represent a quest for sovereignty by the people, but they will all involve different approaches and challenges.
During meetings with the Libyan leaders, Panetta expressed concern about al-Qaida in the Islamic Maghreb militants gaining a foothold amid the chaos of an unfolding democracy. But they told him that the Libyan people will reject the terrorist group, said a senior defense official, who spoke on condition of anonymity because the discussions were private.
Panetta's motorcade from the airport into the city provided views of the nation's violent past and future promise ? lush orange groves, carcasses of bombed buildings and charred and graffiti-covered compound once occupied by Gadhafi. Flying from rooftops were the green, black and red flags, adorned with a star and a crescent, belonging to the new government.
At one point, amid the graffiti splashed across the walls of Gadhafi's former compound was a short comment in English: "Thanx US/UK."
The visit also put the man who has led much of the U.S. terrorism fight over the past several years at the scene of one of the first American wars on terror, more than two centuries ago.
Panetta went to what historians believe is the gravesite of as many as 13 U.S. sailors killed in 1804, when the Navy ship Intrepid exploded while slipping into Tripoli harbor to attack pirate ships that had captured an American frigate.
As the story goes, governments along the Barbary coast had turned to state-sponsored piracy to raise money, attacking and taking over merchant ships, enslaving their crews and stealing their bounties. Unwilling to pay fees to protect its ships, the U.S. sent the Navy frigate Philadelphia to the region but it ran aground just off Tripoli and was captured.
President Thomas Jefferson sent a team to get the Philadelphia back or destroy it. Under cover of darkness, the Intrepid sailed into the harbor, killed about 25 pirates and burned the Philadelphia.
A few months later, Jefferson sent the Intrepid back to destroy as many of the pirate ships as possible. The plan was to pack the ketch with explosives, sail into the harbor and blow her up.
The 13 sailors never got to their destination. The ship exploded prematurely killing all aboard and the next day bodies washed ashore. They were buried outside Tripoli, but in 1949 the remains were moved to The Protestant Cemetery by the Libyan government.
On Saturday, Panetta walked into the small walled cemetery and slowly made his way to a corner where five large but simple white gravestones mark the graves of the American sailors. Markers on four of the stones read, "Here lies an American sailor who gave his life in the explosion of the United States Ship Intrepid in Tripoli Harbour, Sept. 4, 1804."
Panetta placed a wreath at the site and, after a moment of silence, placed one of his U.S. secretary of defense souvenir coins on top of one of the stones.
New life was breathed into the long-ago tale by Congress this year. Lawmakers, prodded by descendants of the sailors, added provisions to the defense bill ordering the Pentagon to study the feasibility of exhuming the bodies and bringing them home to America.
In a statement, Panetta said the recent effort to restore the cemetery is "a symbol of the values we share."
Officials said that Panetta made no specific offers of assistance to the Libyan leaders, and he told reporters that there was no discussion of providing military equipment or weapons.
"They have to determine what their needs are and what kind of assistance is required," he said. "And whatever they need, the United States will be happy to respond."
Ahead of Panetta's visit, the Obama administration announced it had lifted penalties that were imposed on Libya in February to choke off Gadhafi's financial resources while his government was using violence to suppress peaceful protests.
The U.S. at the time blocked some $37 billion in Libyan assets, and a White House statement said Friday's action "unfreezes all government and central bank funds within U.S. jurisdiction, with limited exceptions."
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SAO PAULO (AP) ? A Brazilian judge has revoked a decision that had halted some work on a massive hydroelectric dam in the Amazon jungle.
Federal judge Carlos Eduardo Martins halted construction on the $11-billion, 11,000-megawatt Belo Monte Dam in September, saying it would harm fishing on the Xingu River, which feeds the Amazon.
But on Friday, he ruled that construction could proceed because the Norte Energia consortium that is building the dam showed that the flow of the river would not be altered in a way that would harm the habitat of fish.
The judge's ruling has been posted on the court's website.
When completed, the dam would be the world's third largest behind China's Three Gorges dam and the Itaipu, which straddles the border of Brazil and Paraguay.
The government has said it will be a source of clean, renewable energy, and that it will help fuel the country's economy.
But environmentalists and indigenous groups say the dam would devastate wildlife and the livelihoods of 40,000 people who live in the area to be flooded.
Celebrities including British rock star Sting, film director James Cameron and actress Sigourney Weaver have joined activists in lobbying against the dam.
When Cameron participated in protests against the project in Brazil last year, he compared the anti-dam struggle by indigenous people to the plot of his film "Avatar," which depicts a natives of a planet fighting to protect their homeland from plans to extract its resources.
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